The museum construction started in 1963 under the supervision of the distinguished Greek architect Aris Konstantinidis. The building was ready three years later, but the museum opened to the public in 1970.
The permanent exhibitions had been modified several times due to additional artifacts that were received by the museum over the years. In 2002 there was a major renovation, related to the exterior and the interior of the building which created more space for the displayed exhibits.
There are seven rooms with 3.000 exhibits that are 250 thousand years old and date from the Stone Age, but also findings dating from the 3rd century AD and the Roman period. The majority of the exhibits come from excavations in the region of Epirus and give a clear image of the history of the region making the visitor understand the progress and evolution of the society.